Author

G.-I. Uechi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

P. Laurino· 4 shared B. Cellini· 2 shared M. Dindo· 2 shared S. Pascarelli· 2 shared A. L. Pey· 1 shared B. E. Clifton· 1 shared C. Conter· 1 shared C. Costantini· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBiochemistry

P. Laurino

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Engineered Oxalate decarboxylase boosts activity and stability for biological applications

M. Dindo, C. Conter, G.-I. Uechi, G. Pampalone, L. Ruta, A. L. Pey, L. Rossi, P. Laurino, M. Magnani, B. Cellini

This study engineers Oxalate decarboxylase to improve its activity and stability for medical applications in hyperoxaluria treatment.

bioRxiv · May 6, 2024Biochemistry

Insertions and deletions mediated functional divergence of Rossmann fold enzymes

S. Toledo-Patino, S. Pascarelli, G.-i. Uechi, P. Laurino

The paper identifies how insertions and deletions in Rossmann fold enzymes drove coenzyme specificity shifts from NAD(P) to SAM, revealing evolutionary mechanisms for functional divergence.

bioRxiv · May 16, 2022Evolutionary Biology

Evolutionary repair reveals an unexpected role of the tRNA modification m1G37 in aminoacylation

B. E. Clifton, M. A. Fariz, G.-I. Uechi, P. Laurino

This study uses experimental evolution to show that loss of the tRNA modification m1G37 in E. coli is tolerated via compensatory mutations in the proline-tRNA ligase gene proS, revealing ProRS as a gatekeeper of translational accuracy.

Nucleic Acids Research · Nov 11, 2021Peer-reviewedBiochemistry

Cryptic genetic variations of alanine:glyoxylate aminotransferase shape its fitness and dynamics

M. Dindo, S. Pascarelli, D. Chiasserini, S. Grottelli, C. Costantini, G.-I. Uechi, G. Giardina, P. Laurino, B. Cellini

The paper investigates how genetic variations in AGT1 affect its conformational flexibility and fitness, revealing cryptic functions related to protein-protein interactions.

bioRxiv · May 24, 2021 · PreprintBiochemistry