Author

M. A. Mandell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. Saha· 3 shared G. L. Williams· 2 shared B. Phinney· 1 shared D. C. Chisholm· 1 shared E. Sjottem· 1 shared G. Evjen· 1 shared H. Olsvik· 1 shared M. L. Paffett· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

B. Saha

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

TBK1 is ubiquitinated by TRIM5alpha to assemble mitophagy machinery

B. Saha, H. Olsvik, G. L. Williams, S. Oh, G. Evjen, E. Sjottem, M. A. Mandell

The paper shows TRIM5 ubiquitinates TBK1 to assemble mitophagy machinery on damaged mitochondria, essential for both Parkin-dependent and independent mitophagy.

bioRxiv · Oct 19, 2023Cell Biology

Quantitative single-cell analysis of Leishmania major amastigote differentiation demonstrates variably extended expression of the lipophosphoglycan (LPG) virulence factor in different host cell types

M. A. Mandell, W. L. Beatty, S. M. Beverley

This study uses single-cell analysis to show that Leishmania major amastigotes retain lipophosphoglycan (LPG) expression longer in certain host cells, potentially enhancing infectivity.

bioRxiv · Jun 27, 2022Microbiology

Interactomic analysis reveals a new homeostatic role for the HIV restriction factor TRIM5α in mitophagy

B. Saha, M. R. Salemi, G. L. Williams, M. L. Paffett, B. Phinney, M. A. Mandell

The paper identifies a novel role for TRIM5α in mitophagy, showing it regulates mitochondrial quality control and prevents cell death under mitochondrial stress.

bioRxiv · Aug 20, 2021Cell Biology

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5α.

B. Saha, D. C. Chisholm, M. A. Mandell

This paper shows autophagy proteins are required for TRIM5α to activate antiviral signaling and establish an antiviral state.

bioRxiv · Apr 21, 2020Cell Biology