IN SILICO DESIGN AND BINDING MECHANISM OF E3 LIGASE UBR1 RECRUITERS
M. A. Maria Solano, R. Lazim, S. Choi
The paper designs and analyzes E3 ligase UBR1 recruiters using computational methods to identify promising PROTAC components.
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M. A. Maria Solano, R. Lazim, S. Choi
The paper designs and analyzes E3 ligase UBR1 recruiters using computational methods to identify promising PROTAC components.
A.-r. Han, A. Zhang, H. Kang…·H. M. Kim
This paper presents a high-resolution cryo-EM structure of TMEM87A, revealing its unique architecture and mechanisms of ion conduction and gating in the Golgi apparatus.
This study identifies dynamic allosteric networks in the adenosine A1 receptor that drive activation and G-protein coupling through molecular dynamics simulations and network analysis.