The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling
A. O. Smirnova, A. M. Miroshnichenkova, Y. V. Olshanskaya, M. A. Maschan, Y. B. Lebedev, D. M. Chudakov, I. Mamedov, A. Y. Komkov
The paper introduces a method to correct PCR bias in immune repertoire sequencing by using non-functional clonotypes as a calibrator, improving accuracy across different sequencing approaches.
bioRxiv · Mar 24, 2021Immunology