Cell Mechanics at the Rear Act To Steer the Direction of Cell Migration
G. M. Allen, K. C. Lee, E. L. Barnhart, M. A. Tsuchida, C. A. Wilson, E. Gutierrez, A. Groisman, A. Mogilner, J. A. Theriot
The paper investigates how mechanical asymmetries at the rear of fish keratocytes drive cell turning, showing that actin flow and myosin II contractility, rather than leading edge protrusion, are key to steering migration.
bioRxiv · Oct 15, 2018Cell Biology