Human genetic adaptation related to cellular zinc homeostasis
A. Roca-Umbert, J. Garcia-Calleja, M. Vogel-Gonzalez, A. Fierro-Villegas, G. Ill-Raga, V. Herrera-Fernandez, A. Bosnjak, G. Muntane, E. Gutierrez, F. Campelo, R. Vicente, E. Bosch
This paper identifies directional selection on SLC30A9 haplotypes in Africa and East Asia, showing a gain-of-function variant in ZnT9 linked to mitochondrial metabolism and neuropsychiatric traits.
bioRxiv · Jun 29, 2022 · PreprintEvolutionary Biology