Dysregulated interactions triggered by a neuropathy-causing mutation in the IPV motif of HSP27
T. R. Alderson, E. Adriaenssens, B. Asselbergh, I. Pritisanac, H. Y. Gastall, M. A. Walti, J. M. Louis, V. Timmerman, A. Baldwin, J. L. P. Benesch
This study investigates how the P182L mutation in HSP27's IxI/V motif disrupts protein interactions, leading to aggregation and disease.
bioRxiv · Sep 10, 2019 · PreprintBiochemistry