M. A. Wangeline

An autonomous, but INSIG-modulated, role for the Sterol Sensing Domain in mallostery-regulated ERAD of yeast HMG-CoA reductase

This paper investigates the role of the Hmg2 sterol sensing domain in mallostery-regulated ERAD of yeast HMGR, showing its autonomous function and modulation by INSIG proteins.

Ligand-regulated entry into the HRD ERAD pathway--the dark side of allostery

This study shows GGPP induces Hmg2 misfolding and degradation via an allosteric mechanism, suggesting a new regulatory strategy with pharmaceutical potential.