Author

R. Y. Hampton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cell Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:yeast· 2 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1 Assay:proteomics· 1

Frequent Co-Authors

M. A. Wangeline· 2 shared

Activity by Year

2018-2020 · peak 1/yr

2 papers

Recent·Most cited

Cell BiologybioRxivAug 20, 2020

An autonomous, but INSIG-modulated, role for the Sterol Sensing Domain in mallostery-regulated ERAD of yeast HMG-CoA reductase

M. A. Wangeline, R. Y. Hampton

This paper investigates the role of the Hmg2 sterol sensing domain in mallostery-regulated ERAD of yeast HMGR, showing its autonomous function and modulation by INSIG proteins.

DOI 10.1074/jbc.ra120.015910

yeastproteomics

𝕏 PostBluesky

Cell BiologyJournal of Biological ChemistryPeer-reviewedSep 1, 2018

Ligand-regulated entry into the HRD ERAD pathway--the dark side of allostery

M. A. Wangeline, R. Y. Hampton

This study shows GGPP induces Hmg2 misfolding and degradation via an allosteric mechanism, suggesting a new regulatory strategy with pharmaceutical potential.

DOI 10.1074/jbc.ra118.001808

yeastprotein structure

𝕏 PostBluesky