M. Aguilar

Large- and Small-Animal Studies of Safety, Pharmacokinetics (PK), and Biodistribution of Inflammasome-Targeting Nanoligomer in the Brain and Other Target Organs

This paper evaluates the safety, pharmacokinetics, and biodistribution of an inflammasome-targeting Nanoligomer cocktail in small and large animals across multiple administration routes.

Improved detection and phylogenetic analysis of plant proteins containing LysM domains.

The paper improves LysM domain detection in plant RLK/Ps using enhanced HMMs and evaluates ligand-specific classification.

Spatial autocorrelation dimension as a potential determinant for the temporal persistence of human atrial and ventricular fibrillation.

The paper investigates whether the spatial autocorrelation dimension (Di) predicts the time to termination of human atrial and ventricular fibrillation.

A morphological basis for path dependent evolution of visual systems

The paper demonstrates path-dependent evolution of visual systems in chitons, showing that the number of optic nerve openings constrains the type of visual system that evolves.

Under pressure: phenotypic divergence and convergence associated with microhabitat adaptations in Triatominae

This study identifies phenotypic divergence and convergence in Rhodnius ecuadoriensis populations linked to microhabitat adaptations, revealing ecological pressures shaping phenotypic variation.

Renewal theory provides a universal quantitative framework to characterise the continuous regeneration of rotational events in cardiac fibrillation

The paper applies renewal theory to model phase singularity dynamics in cardiac fibrillation across species, finding exponential inter-event time distributions with consistent rate parameters.

Numb prevents a complete EMT by modulating Notch signalling

This study shows Numb stabilizes a hybrid E/M phenotype by inhibiting Notch-driven full EMT, correlates with poor cancer survival, and predicts its role in tumor-initiation.