F. Bocci

Nrf2 modulates the hybrid epithelial/mesenchymal phenotype and Notch signaling during collective cancer migration

This study shows Nrf2 stabilizes hybrid epithelial/mesenchymal cells and coordinates Notch signaling during collective cancer migration.

Investigating epithelial-mesenchymal heterogeneity of tumors and circulating tumor cells with transcriptomic analysis and biophysical modeling

This study investigates the relationship between epithelial-mesenchymal plasticity in tumors and circulating tumor cells using transcriptomic analysis and biophysical modeling, finding no consistent correlation between EMT traits in tumors and CTCs.

A biophysical model uncovers the size distribution of migrating cell clusters across cancer types

This paper develops a biophysical model to explain cancer cell migration modes, showing that partial EMT and cooperative mechanisms can generate cluster size distributions observed across cancer types.

NRF2 activates a partial Epithelial-Mesenchymal Transition and is maximally present in a hybrid Epithelial/Mesenchymal phenotype

This study shows NRF2 stabilizes a hybrid epithelial/mesenchymal phenotype by upregulating both E-cadherin and ZEB, and correlates this phenotype with poor survival in cancer.

Towards understanding cancer stem cell heterogeneity in the tumor microenvironment

This paper develops a computational-experimental framework to explain the spatial heterogeneity of cancer stem cells in the tumor microenvironment, showing that Notch-JAG1 signaling and inflammatory cytokines drive CSC distribution and stemness.

A mechanism-based computational model to capture the interconnections among epithelial-mesenchymal transition, cancer stem cells and Notch-Jagged signaling

The paper develops a computational model to explore the interactions between EMT, CSCs, and Notch-Jagged signaling, revealing how hybrid E/M cells with stemness traits and enhanced Notch-Jagged signaling contribute to therapeutic resistance.

PAGE4 and Conformational Switching: Insights from Molecular Dynamics Simulations and Implications for Prostate Cancer

This study uses molecular dynamics simulations to investigate how phosphorylation of PAGE4 affects its structure and interactions with AP-1 and AR, revealing conformational switching linked to prostate cancer progression.

Numb prevents a complete EMT by modulating Notch signalling

This study shows Numb stabilizes a hybrid E/M phenotype by inhibiting Notch-driven full EMT, correlates with poor cancer survival, and predicts its role in tumor-initiation.