Author

S. Willems

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

F. Meier· 2 shared M. Mann· 2 shared M. Thielert· 2 shared P. Skowronek· 2 shared A. G. McGavigan· 1 shared A. Lahiri· 1 shared A. N. Ganesan· 1 shared A. Paucarmayta· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

F. Meier

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Synchro-PASEF allows precursor-specific fragment ion extraction and interference removal in data-independent acquisition

P. Skowronek, F. Krohs, M. Lubeck, G. Wallmann, E. Itang, P. Koval, M. Wahle, M. Thielert, F. Meier, S. Willems, O. Raether, M. Mann

This paper introduces synchro-PASEF, a method that improves fragment ion extraction and interference removal in DIA proteomics by synchronizing ion mobility and mass dimensions.

bioRxiv · Nov 1, 2022Biochemistry

Rapid and in-depth coverage of the (phospho-)proteome with deep libraries and optimal window design for dia-PASEF

P. Skowronek, M. Thielert, E. Voytik, M. C. Tanzer, F. M. Hansen, S. Willems, O. Karayel, A.-D. Brunner, F. Meier, M. Mann

This paper introduces an optimized dia-PASEF method with variable isolation windows to enhance proteome and phosphoproteome coverage in mass spectrometry.

bioRxiv · May 31, 2022Biochemistry

Cancer immunotherapy by NC410, a LAIR-2 Fc protein blocking LAIR-collagen interaction

M. I. P. Ramos, L. Tian, E. J. de Ruiter, C. Song, A. Paucarmayta, A. Singh, E. Elshof, S. V. Vijver, J. Shaik, J. Bosiacki, Z. Cusumano, L. Liu, S. Langermann, S. Willems, D. Flies, L. Meyaard

The paper demonstrates that NC410, a LAIR-2 Fc protein, blocks LAIR-1-collagen interaction, enhancing T cell activity and reducing tumor growth in humanized models.

bioRxiv · Oct 21, 2020Cancer Biology

Renewal theory provides a universal quantitative framework to characterise the continuous regeneration of rotational events in cardiac fibrillation

D. Dharmaprani, M. Schopp, P. Kuklik, D. Chapman, A. Lahiri, L. Dykes, F. Xiong, M. Aguilar, B. Strauss, L. Mitchell, K. Pope, C. Meyer, S. Willems, F. G. Akar, S. Nattel, , A. N. Ganesan

The paper applies renewal theory to model phase singularity dynamics in cardiac fibrillation across species, finding exponential inter-event time distributions with consistent rate parameters.

bioRxiv · Apr 4, 2019 · PreprintPhysiology