Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population
A. Z. Wang, B. L. Mashimo, M. O. Schaettler, N. D. Sherpa, L. A. Leavitt, A. J. Livingstone, S. M. Khan, M. Li, M. Anzaldua-Campos, J. D. Bradley, E. C. Leuthardt, A. H. Kim, J. L. Dowling, M. R. Chicoine, P. S. Jones, , G. P. Dunn
The paper analyzes TILs in GBM using CITE-seq and scRNA-seq to show that CD8+ T cells are predominantly clonally expanded GZMK+ effector cells, lacking canonical exhaustion.
bioRxiv · Aug 25, 2023 · PreprintImmunology