Author

A. Z. Wang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 4 Research Focus:differential expression· 3 Approach:experimental assay· 3 Assay:scRNA-seq· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2

Frequent Co-Authors

A. A. Petti· 2 shared A. H. Kim· 2 shared A. J. Livingstone· 2 shared E. C. Leuthardt· 2 shared G. P. Dunn· 2 shared M. O. Schaettler· 2 shared M. R. Chicoine· 2 shared R. Desai· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersImmunology

A. A. Petti

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population

A. Z. Wang, B. L. Mashimo, M. O. Schaettler, N. D. Sherpa, L. A. Leavitt, A. J. Livingstone, S. M. Khan, M. Li, M. Anzaldua-Campos, J. D. Bradley, E. C. Leuthardt, A. H. Kim, J. L. Dowling, M. R. Chicoine, P. S. Jones, , G. P. Dunn

The paper analyzes TILs in GBM using CITE-seq and scRNA-seq to show that CD8+ T cells are predominantly clonally expanded GZMK+ effector cells, lacking canonical exhaustion.

bioRxiv · Aug 25, 2023 · PreprintImmunology

DUSP6 mediates resistance to JAK2 inhibition and drives leukemic progression

T. Kong, A. B. A. Laranjeira, K. Yang, D. Fisher, L. Yu, A. Z. Wang, M. Ruzinova, J. Fowles, M. Allen, H. Celik, G. Challen, S. Huang, S. Oh

This study identifies DUSP6 as a driver of leukemic progression and resistance to JAK2 inhibition in MPNs, highlighting the DUSP6-RSK1 axis as a therapeutic target.

Nature Cancer · Dec 29, 2022Peer-reviewedCancer Biology

The conventional dendritic cell 1 subset primes CD8+ T cells and traffics tumor antigen to drive anti-tumor immunity in the brain

J. A. Bowman-Kirigin, B. T. Saunders, R. Desai, A. Z. Wang, M. O. Schaettler, C. J. Liu, A. J. Livingstone, D. K. Kobayashi, V. Durai, N. M. Kretzer, G. J. Zipfel, E. C. Leuthardt, J. W. Osbun, M. R. Chicoine, A. H. Kim, , G. P. Dunn

The paper identifies cDC1's role in priming CD8+ T cells and trafficking tumor antigens to drive anti-tumor immunity in the brain.

bioRxiv · Sep 13, 2021Immunology

Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response

A. Z. Wang, J. Bowman-Kirigin, R. Desai, P. Patel, B. Patel, S. Khan, D. Bender, M. C. Marlin, J. Liu, J. Osbun, E. Leuthardt, M. Chicoine, R. Dacey, G. Zipfel, A. Kim, , G. Dunn

This study uses single-cell RNA-sequencing to characterize human dura and meningioma, revealing distinct immune microenvironments and TCR overlap between matched samples.

bioRxiv · Aug 3, 2021 · PreprintImmunology

Prostate-Specific Antigen Dynamics Predict Individual Responses to Intermittent Androgen Deprivation

R. Brady, J. Nagy, T. Gerke, T. Zhang, A. Z. Wang, J. Zhang, R. Gatenby, H. Enderling

The paper uses mathematical models of prostate cancer stem cell dynamics to predict individual responses to intermittent androgen deprivation therapy based on prostate-specific antigen (PSA) measurements.

bioRxiv · May 2, 2019 · PreprintCancer Biology