S. M. Khan

Glioblastoma-infiltrating CD8+ T cells are predominantly a clonally expanded GZMK+ effector population

The paper analyzes TILs in GBM using CITE-seq and scRNA-seq to show that CD8+ T cells are predominantly clonally expanded GZMK+ effector cells, lacking canonical exhaustion.

Single-cell multi-omic analysis of the vestibular schwannoma ecosystem uncovers a nerve injury-like state

The paper analyzes single-cell multi-omic data from vestibular schwannomas to identify a nerve injury-like state in tumor-associated Schwann cells linked to myeloid cell recruitment and tumor growth.

Evolution of influenza A virus hemagglutinin H1 and H3 across host species

This study compares the evolutionary rates of influenza A virus hemagglutinin H1 and H3 across different host species, finding higher nonsynonymous mutation rates in mammals and specific glycosylation site accumulation in humans and swine.

Allosteric priming of E. coli CheY by the flagellar motor protein FliM

This study uses molecular dynamics and experimental methods to show that phosphorylation of CheY increases its affinity for FliMN by altering conformational dynamics and sidechain burial.

An interaction between Gβγ and RNA polymerase II regulates transcription in cardiac fibroblasts

The paper shows Gβγ interacts with RNA polymerase II in cardiac fibroblasts, negatively regulating fibrotic gene expression, with cell-specific signaling pathways involved.

Probabilistic data integration identifies reliable gametocyte-specific proteins and transcripts in malaria parasites

The paper integrates omics data to identify gametocyte-specific genes and transcripts in malaria parasites, finding novel biomarkers and validating their expression in natural infections.