Cytosolic and mitochondrial translation elongation are coordinated through the molecular chaperone TRAP1 for the synthesis and import of mitochondrial proteins
R. Avolio, I. Agliarulo, D. Criscuolo, D. Sarnataro, M. Auriemma, S. Pennacchio, G. Calice, M. Y. Ng, C. Giorgi, P. Pinton, B. Cooperman, M. Landriscina, F. Esposito, D. S. Matassa
The paper identifies TRAP1's role in coordinating cytosolic and mitochondrial translation elongation for mitochondrial protein synthesis and import, revealing a feedback loop between protein synthesis and energy metabolism in cancer cells.
bioRxiv · Jan 19, 2023Biochemistry