Thioesterase Superfamily Member 1 Undergoes Stimulus-coupled Reorganization to Regulate Metabolism
Y. Li, N. Imai, S. Goyal, H. T. Nicholls, T. I. Krisko, M. Baqai, L.-H. Ang, M. C. Tillman, E. A. Ortlund, D. E. Cohen, S. J. Hagen
This paper shows that Them1 undergoes conformational changes in response to stimuli, forming biomolecular condensates that regulate fatty acid oxidation and thermogenesis.
bioRxiv · Feb 18, 2020Cell Biology