Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4+ helper and CD8+ effector T cells
A. C. Azevedo-Pouly, L. E. Appell, L. Burdine, L. J. Rogers, L. C. Morehead, M. Barker, Z. J. Waldrip, B. Koss, M. S. Burdine
This study shows DNA-PKcs inhibition reduces T cell activation, cytotoxicity, and metabolic activity in both murine and human models, suggesting its therapeutic potential for immune-related diseases.
bioRxiv · Jun 23, 2022 · PreprintImmunology