Author

L. C. Morehead

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1

Frequent Co-Authors

A. C. Azevedo-Pouly· 1 shared A. J. Tackett· 1 shared B. Koss· 1 shared E. R. Siegel· 1 shared I. R. Miousse· 1 shared K. F. Wallis· 1 shared L. Burdine· 1 shared L. E. Appell· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperImmunology

A. C. Azevedo-Pouly

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Increased response to immune checkpoint inhibitors with dietary methionine restriction

L. C. Morehead, S. Garg, K. F. Wallis, E. R. Siegel, A. J. Tackett, I. R. Miousse

This study shows that dietary methionine restriction enhances immune checkpoint inhibitor efficacy in mice by increasing MHC-I and PD-L1 expression via the cGAS-STING pathway and interferon signaling.

bioRxiv · Apr 5, 2023 · PreprintCancer Biology

Inhibition of DNA-PKcs impairs the activation and cytotoxicity of CD4+ helper and CD8+ effector T cells

A. C. Azevedo-Pouly, L. E. Appell, L. Burdine, L. J. Rogers, L. C. Morehead, M. Barker, Z. J. Waldrip, B. Koss, M. S. Burdine

This study shows DNA-PKcs inhibition reduces T cell activation, cytotoxicity, and metabolic activity in both murine and human models, suggesting its therapeutic potential for immune-related diseases.

bioRxiv · Jun 23, 2022 · PreprintImmunology