Compartmentalized lymph node drainage dictates intestinal adaptive immune responses
D. Esterhazy, M. C. Canesso, P. A. Muller, A. Lockhart, L. Mesin, A. M. Faria, D. Mucida
This study shows that mesenteric lymph nodes (mLNs) along the intestine are functionally distinct, with proximal mLNs promoting tolerance and distal mLNs driving inflammation, and demonstrates how disruptions in this compartmentalization affect immune responses.
bioRxiv · Apr 12, 2018Immunology