Author

A. Lockhart

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

D. Mucida· 4 shared A. Reed· 2 shared B. S. Reis· 2 shared D. Esterhazy· 2 shared M. C. C. Canesso· 2 shared A. Bilate· 1 shared A. M. Faria· 1 shared C. Herman· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersImmunology

D. Mucida

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4 papers

Recent·Most cited

Dietary protein shapes the profile and repertoire of intestinal CD4+ T cells

A. Lockhart, A. Reed, T. B. R. de Castro, C. Herman, M. C. C. Canesso, D. Mucida

This study shows dietary proteins influence intestinal CD4+ T cell profiles and receptor repertoires, affecting their transcriptional programs and responses to food antigens.

bioRxiv · Apr 11, 2023 · PreprintImmunology

Identification of dendritic cell-T cell interactions driving immune responses to food

M. C. C. Canesso, T. B. Castro, S. Nakandakari-Higa, A. Lockhart, D. Esterhazy, B. S. Reis, G. D. Victora, D. Mucida

This study identifies dendritic cell subsets that drive immune responses to dietary antigens, showing that cDC1s induce regulatory T cells while cDC2s promote pro-inflammatory responses.

bioRxiv · Oct 26, 2022 · PreprintImmunology

Vγ usage distinguishes pro- and anti-tumor intestinal γδ T cell subsets

B. S. Reis, P. W. Darcy, I. Z. Khan, O. Eleso, C. Zhu, M. Schernthanner, A. Lockhart, A. Reed, J. Bortolatto, T. Castro, A. Bilate, S. Grivennikov, D. Mucida

The paper identifies Vγ1+ and Vγ7+ γδ T cells as anti-tumor and RORγt+ subsets, including Vγ4+ and Vγ6+, as pro-tumor in colorectal cancer.

bioRxiv · Nov 13, 2021 · PreprintImmunology

Compartmentalized lymph node drainage dictates intestinal adaptive immune responses

D. Esterhazy, M. C. Canesso, P. A. Muller, A. Lockhart, L. Mesin, A. M. Faria, D. Mucida

This study shows that mesenteric lymph nodes (mLNs) along the intestine are functionally distinct, with proximal mLNs promoting tolerance and distal mLNs driving inflammation, and demonstrates how disruptions in this compartmentalization affect immune responses.

bioRxiv · Apr 12, 2018Immunology