Author

M. C. Childers

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2

Frequent Co-Authors

M. Regnier· 2 shared A. Dawood· 1 shared A. L. Wacker· 1 shared B. A. Whitson· 1 shared B. J. Biesiadecki· 1 shared D. Bhowmik· 1 shared E. A. Brundage· 1 shared H. He· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBiochemistry

M. Regnier

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2 papers

Recent·Most cited

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically

N. Nandwani, D. Bhowmik, M. C. Childers, R. R. Goluguri, A. Dawood, M. Regnier, J. A. Spudich, K. M. Ruppel

This study investigates how HCM mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin, leading to hypercontractility by destabilizing the OFF-state.

bioRxiv · Feb 29, 2024Biochemistry

Post-translational modification patterns on β-myosin heavy chain are altered in ischemic and non-ischemic human hearts

M. S. Parvatiyar, M. Landim-Vieira, M. C. Childers, A. L. Wacker, M. R. Garcia, H. He, R. Singh, E. A. Brundage, J. R. Johnston, B. A. Whitson, P. B. Chase, P. M. Janssen, M. Regnier, B. J. Biesiadecki, J. R. Pinto

The paper identifies PTMs on β-MHC in human hearts and shows their changes in failing hearts, suggesting acetylation levels are influenced by PTM location rather than disease type.

bioRxiv · Nov 21, 2021Physiology