Author

N. Nandwani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

J. A. Spudich· 2 shared K. M. Ruppel· 2 shared A. Dawood· 1 shared A. Grinzato· 1 shared A. Houdusse· 1 shared C. Kikuti· 1 shared D. Auguin· 1 shared D. Bhowmik· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

J. A. Spudich

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2 papers

Recent·Most cited

Hypertrophic cardiomyopathy mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin allosterically

N. Nandwani, D. Bhowmik, M. C. Childers, R. R. Goluguri, A. Dawood, M. Regnier, J. A. Spudich, K. M. Ruppel

This study investigates how HCM mutations Y115H and E497D disrupt the folded-back state of human beta-cardiac myosin, leading to hypercontractility by destabilizing the OFF-state.

bioRxiv · Feb 29, 2024Biochemistry

Cryo-EM structure of the folded-back state of human β-cardiac myosin

A. Grinzato, D. Auguin, C. Kikuti, N. Nandwani, D. Moussaoui, D. Pathak, E. Kandiah, K. M. Ruppel, J. A. Spudich, A. Houdusse, J. Robert-Paganin

The paper reports the 3.6 Å cryo-EM structure of the folded-back IHM state of human β-cardiac myosin, revealing HCM mutation hotspots and structural differences from smooth muscle myosin IHMs.

bioRxiv · Apr 15, 2023 · PreprintBiophysics