ApoC-III helical structure determines its ability to bind plasma lipoproteins and inhibit Lipoprotein Lipase-mediated triglyceride lipolysis.
C. Vitali, S. Stankov, S. A. Khetarpal, J. Millar, L. Mayne, S. W. Englander, N. J. Hand, S. Lund-Katz, M. C. Phillips, D. J. Rader
This study investigates how structural changes in apoC-III affect its interaction with lipoproteins and LPL activity, revealing that hydrophilic-lipophilic properties of alpha helices modulate triglyceride levels.
bioRxiv · Jul 2, 2020 · PreprintBiochemistry