Author

M. Chamberlain

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:clustering· 1

Frequent Co-Authors

E. de Rinaldis· 2 shared R. Hanamsagar· 2 shared V. Savova· 2 shared A. Amer· 1 shared A. Hochschild· 1 shared C. D. Wells· 1 shared F. Nestle· 1 shared F. O. Nestle· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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2 shared papersImmunology

E. de Rinaldis

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Septin Cytoskeleton is Required for Plasma Membrane Repair

M. I. A. Prislusky, J. G. Lam, V. Ruiz Contreras, M. Ng, M. Chamberlain, S. Pathak-Sharma, M. Fields, X. Zhang, A. Amer, S. M. Seveau

This study identifies SEPT7 as a critical component of the septin cytoskeleton required for plasma membrane repair, showing its role in forming repair domains with F-actin and ANXA2.

bioRxiv · Jul 12, 2023Cell Biology

Cell type classification and discovery across diseases, technologies and tissues reveals conserved gene signatures and enables standardized single-cell readouts

M. Chamberlain, R. Hanamsagar, F. O. Nestle, E. de Rinaldis, V. Savova

The paper introduces Signac, a machine learning method for classifying single-cell RNA-sequencing data across diseases and tissues, and identifies drug targets in rheumatoid arthritis.

bioRxiv · Feb 1, 2021 · PreprintImmunology

An optimized workflow for single-cell transcriptomics and repertoire profiling of purified lymphocytes from clinical samples.

R. Hanamsagar, T. Reizis, M. Chamberlain, R. Marcus, F. Nestle, E. de Rinaldis, V. Savova

The paper optimizes workflows for single-cell transcriptomics and repertoire profiling of purified lymphocytes from clinical samples, identifying best practices for viability, yield, and data quality.

bioRxiv · Nov 4, 2019Immunology

Alternative transcription cycle for bacterial RNA polymerase

T. T. Harden, K. S. Herlambang, M. Chamberlain, J.-B. Lalanne, C. D. Wells, G.-W. Li, R. Landick, A. Hochschild, J. Kondev, J. Gelles

The paper observes bacterial RNA polymerase (RNAP) remaining bound to DNA after termination and restarting transcription in reverse, producing antisense transcripts, using single-molecule fluorescence microscopy and genome-wide RNA sequencing.

bioRxiv · Jun 11, 2019Biophysics