Author

J.-B. Lalanne

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G.-W. Li· 4 shared A. Hochschild· 1 shared C. D. Wells· 1 shared D. J. Parker· 1 shared D. M. McCormick· 1 shared J. Gelles· 1 shared J. Kondev· 1 shared K. S. Herlambang· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersBiophysics

G.-W. Li

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4 papers

Recent·Most cited

First-principles model of optimal translation factors stoichiometry

J.-B. Lalanne, G.-W. Li

The paper develops a first-principles biophysical model to predict optimal translation factor stoichiometry by maximizing ribosome usage under proteome allocation constraints.

bioRxiv · Apr 2, 2021Biophysics

Translational activation by an alternative sigma factor in Bacillus subtilis

D. M. McCormick, J.-B. Lalanne, T. C. T. Lan, S. Rouskin, G.-W. Li

The paper shows that the sigma factor σB in Bacillus subtilis induces translation of its regulon genes by relieving RNA secondary structures, leading to significant translation efficiency differences compared to σA.

bioRxiv · Mar 6, 2021Microbiology

Spurious regulatory connections dictate the expression-fitness landscape of translation termination factors

J.-B. Lalanne, D. J. Parker, G.-W. Li

The paper quantifies how varying expression of translation termination factors in Bacillus subtilis affects fitness, revealing spurious regulatory connections that reduce fitness when expression deviates from endogenous levels.

bioRxiv · Nov 27, 2020Biophysics

Alternative transcription cycle for bacterial RNA polymerase

T. T. Harden, K. S. Herlambang, M. Chamberlain, J.-B. Lalanne, C. D. Wells, G.-W. Li, R. Landick, A. Hochschild, J. Kondev, J. Gelles

The paper observes bacterial RNA polymerase (RNAP) remaining bound to DNA after termination and restarting transcription in reverse, producing antisense transcripts, using single-molecule fluorescence microscopy and genome-wide RNA sequencing.

bioRxiv · Jun 11, 2019Biophysics