Inhibition of proline-rich-tyrosine kinase 2 restores cardioprotection by remote ischemic preconditioning in type 2 diabetes mellitus
R. Erkens, D. A. Duse, A. Brum, A. Chadt, S. Becher, M. Siragusa, C. Quast, J. Muessig, M. Roden, M. Cortese-Krott, E. Lammert, I. Fleming, C. Jung, H. Al-Hasani, G. Heusch, M. Kelm
This study shows that inhibiting Pyk2 restores cardioprotection lost in diabetes through improved endothelial function and eNOS activity during remote ischemic preconditioning.
bioRxiv · Apr 25, 2023 · PreprintPhysiology