M. Kelm

Novel fluorescence-based methods to determine infarct and scar size in murine models of reperfused myocardial infarction

The paper compares fluorescence staining methods to classical histochemical techniques for determining infarct and scar size in murine reperfused myocardial infarction models.

Impaired mitochondrial ketone body oxidation in insulin resistant states

This study shows reduced mitochondrial ketone body oxidation in insulin resistant states across multiple organs in humans and mice.

Crosstalk between thrombospondin-1 and CD36 modulates platelet-RBC interaction limiting thrombosis and abdominal aneurysm formation

This study identifies a novel CD36-TSP-1 signaling pathway that modulates platelet-RBC interaction, promoting thrombus formation and contributing to abdominal aortic aneurysm pathology.

Inhibition of proline-rich-tyrosine kinase 2 restores cardioprotection by remote ischemic preconditioning in type 2 diabetes mellitus

This study shows that inhibiting Pyk2 restores cardioprotection lost in diabetes through improved endothelial function and eNOS activity during remote ischemic preconditioning.

Inhibition of CD40-TRAF6 signaling protects against aneurysm development and progression

This study shows that inhibiting CD40-TRAF6 signaling reduces abdominal aortic aneurysm severity and progression in mice.

Using TCR and BCR sequencing to unravel the role of T and B cells in abdominal aortic aneurysm

This study uses scRNA TCR and BCR sequencing to analyze T and B cell responses in murine AAA, finding no clonal expansion of TCRs or BCRs.

Quantitative assessment of angioplasty induced vascular inflammation with 19F cardiovascular magnetic resonance imaging

This study uses 19F MRI to quantify monocyte/macrophage infiltration after vascular injury with sufficient sensitivity.

Platelet pannexin-1 channels modulate inflammation during abdominal aortic aneurysm formation

This study investigates the role of platelet pannexin-1 channels in inflammation during abdominal aortic aneurysm formation and finds that their modulation does not affect AAA progression.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.