Octapeptin C4 Induces Less Resistance and Novel Mutations in an Epidemic Carbapenemase-producing Klebsiella pneumoniae ST258 Clinical Isolate Compared to Polymyxins
M. Pitt, M. D. Cao, M. Butler, S. Ramu, D. Ganesamoorthy, M. Blaskovich, L. Coin, M. Cooper
This study compares resistance development in XDR Klebsiella pneumoniae ST258 exposed to polymyxins and octapeptin C4, finding OctC4 induces less resistance and novel mutations.
bioRxiv · Apr 28, 2018Microbiology