M. Blaskovich

Heterogeneous efflux pump expression underpins phenotypic resistance to antimicrobial peptides

This study shows that subpopulations of stationary phase bacteria resist antimicrobial peptides through enhanced efflux and other mechanisms, and suggests combining tachyplesin with sertraline to combat resistance.

Phage-induced efflux down-regulation boosts antibiotic efficacy

This study shows that phage presence reduces antibiotic efflux in bacteria, enhancing antibiotic efficacy and enabling lower concentrations for treatment.

Nitroimidazopyrazinones with oral activity against tuberculosis and Chagas disease in mouse models of infection

This paper evaluates nitroimidazopyrazinone derivatives for antitubercular and antiparasitic activity, showing selectivity against M. tuberculosis and efficacy against T. cruzi in mouse models.

Fast bacterial growth reduces antibiotic accumulation and efficacy

The paper identifies fast-growing bacterial variants that avoid antibiotic accumulation and survive treatment without genetic mutations, challenging the current understanding of antibiotic resistance mechanisms.

Octapeptin C4 Induces Less Resistance and Novel Mutations in an Epidemic Carbapenemase-producing Klebsiella pneumoniae ST258 Clinical Isolate Compared to Polymyxins

This study compares resistance development in XDR Klebsiella pneumoniae ST258 exposed to polymyxins and octapeptin C4, finding OctC4 induces less resistance and novel mutations.