Author

M. D. Distefano

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:proteomics· 4 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

K. Justyna· 2 shared L. Li· 2 shared S. A. Auger· 2 shared S. Maity· 2 shared A. Jeong· 1 shared A. Petre· 1 shared C. G. Ousley· 1 shared D. B. McKim· 1 shared

Activity by Year

2022-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersBiochemistry

K. Justyna

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Improved synthesis and application of an alkyne-functionalized isoprenoid analogue to study the prenylomes of motor neurons, astrocytes and their stem cell progenitors

K. Suazo, V. Mishra, S. Maity, S. Auger, K. Justyna, A. Petre, L. Ottoboni, J. Ongaro, S. Corti, F. Lotti, S. Przedborski, M. D. Distefano

The paper improves the synthesis of C15AlkOPP and uses it to label and analyze prenylated proteins in motor neurons, astrocytes, and their stem cell progenitors, identifying 54, 50, and 84 prenylated proteins respectively.

bioRxiv · Mar 3, 2024Biochemistry

Mevalonate metabolites contribute to granulocyte chemotaxis and mortality in murine endotoxemia

J. Hussain, C. G. Ousley, S. A. Krauklis, E. L. Dray, J. Drnevich, K. Justyna, M. D. Distefano, D. B. McKim

This study shows that statin pretreatment improves survival in murine endotoxemia by reducing granulocyte chemotaxis through geranylgeranylation inhibition.

bioRxiv · Sep 13, 2022 · PreprintImmunology

Thinking outside the CaaX-box: an unusual reversible prenylation on ALDH9A1

K. F. Suazo, G. L. Schey, S. A. Auger, L. Li, M. D. Distefano

The paper identifies a novel reversible prenylation on ALDH9A1 lacking a canonical prenylation motif, revealing a new type of protein-lipid modification.

bioRxiv · Aug 29, 2022Biochemistry

In vivo prenylomic profiling in the brain of a transgenic mouse model of Alzheimer's disease reveals increased prenylation of a key set of proteins

A. Jeong, S. A. Auger, S. Maity, L. Li, M. D. Distefano

The paper uses prenylomic analysis in AD mice to identify 36 prenylated proteins, with 15 showing increased levels, suggesting potential therapeutic targets.

bioRxiv · Apr 1, 2022Biochemistry