Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells
J. L. Rausch, A. A. Ali, D. M. Lee, Y. K. Gebreyohannes, K. R. Mehalek, A. Agha, S. S. Patil, Y. Tolstov, J. Wellens, H. S. Dhillon, K. R. Makielski, M. Debiec-Rychter, P. Schoeffski, A. Wozniak, A. Duensing
This study evaluates second-generation proteasome inhibitors and ubiquitination regulators for their efficacy against imatinib-resistant GIST cells, finding that 20S proteasome inhibitors are effective while others show limited activity.
bioRxiv · Jan 9, 2020Cancer Biology