Author

D. M. Lee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:electronic health records· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

A. Duensing· 2 shared J. L. Rausch· 2 shared M. Mettlen· 2 shared S. L. Schmid· 2 shared S. S. Patil· 2 shared A. A. Ali· 1 shared A. A. Amir· 1 shared A. Agha· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersCancer Biology

A. Duensing

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Endocytosis gated by emergent properties of membrane-clathrin interactions

X. Wang, Y. Li, A. Liu, R. Padilla, D. M. Lee, D. Kim, M. Mettlen, Z. Chen, S. L. Schmid, G. Danuser

This paper models clathrin-mediated endocytosis to show that the switch between productive and abortive CCPs is an emergent property of clathrin-membrane interactions and EAPs.

bioRxiv · Aug 2, 2023 · PreprintBiophysics

Targeting the translational machinery in gastrointestinal stromal tumors (GIST) - a new therapeutic vulnerability

D. M. Lee, A. Sun, S. S. Patil, L. Liu, A. V. Rao, P. T. Trent, A. A. Amir, C. Liu, J. L. Rausch, L. D. Presutti, A. Kaczorowski, F. Schneider, N. Amankulor, M. Shuda, A. Duensing

This study shows that homoharringtonine (HHT) effectively inhibits KIT-dependent GIST growth by reducing protein synthesis, even in imatinib-resistant models.

bioRxiv · Sep 1, 2021Cancer Biology

Differential antitumor activity of compounds targeting the ubiquitin-proteasome machinery in gastrointestinal stromal tumor (GIST) cells

J. L. Rausch, A. A. Ali, D. M. Lee, Y. K. Gebreyohannes, K. R. Mehalek, A. Agha, S. S. Patil, Y. Tolstov, J. Wellens, H. S. Dhillon, K. R. Makielski, M. Debiec-Rychter, P. Schoeffski, A. Wozniak, A. Duensing

This study evaluates second-generation proteasome inhibitors and ubiquitination regulators for their efficacy against imatinib-resistant GIST cells, finding that 20S proteasome inhibitors are effective while others show limited activity.

bioRxiv · Jan 9, 2020Cancer Biology

The mechanisms of dynamin-actin interaction

R. Zhang, N. Gerassimov, D. M. Lee, J. R. Jimah, S. Kim, D. Luvsanjav, J. Winkelman, M. Mettlen, M. E. Abrams, R. Kalia, P. Keene, P. Pandey, B. Ravaux, J. H. Kim, J. A. Ditlev, , E. H. Chen

This study identifies a noncanonical role for dynamin in cell-cell fusion by directly bundling actin filaments through GTPase-dependent interactions.

bioRxiv · Mar 25, 2019 · PreprintCell Biology