An mRNA-encoded, long-lasting Interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers
J. D. Beck, M. Diken, M. Suchan, M. Streuber, E. Diken, L. Kolb, L. Allnoch, F. Vascotto, D. Peters, T. Beissert, O. Tuereci, S. Kreiter, M. Vormehr, U. Sahin
The paper shows that long-lasting mRNA-encoded IL2 restores immune responses in MHC class I-deficient cancers by activating neoantigen-specific CD8+ T cells.
bioRxiv · Jul 18, 2023Immunology