Author

U. Sahin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:host-pathogen & immune response· 9 Organism:human· 8 Assay:proteomics· 5 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:clinical cohort / trial· 1 Approach:deep learning· 1

Frequent Co-Authors

A. Muik· 9 shared O. Tuereci· 6 shared H. Cai· 5 shared K. A. Swanson· 5 shared A.-K. Wallisch· 4 shared B. G. Lui· 4 shared K. Grikscheit· 4 shared M. Bacher· 4 shared

Activity by Year

2021-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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9 shared papersImmunology

A. Muik

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

FrameDiPT: SE(3) Diffusion Model for Protein Structure Inpainting

C. Zhang, A. Leach, T. Makkink, M. Arbesu, I. Kadri, D. Luo, L. Mizrahi, S. Krichen, M. Lang, A. Tovchigrechko, N. Lopez Carranza, U. Sahin, K. Beguir, M. Rooney, Y. Fu

FrameDiPT is a diffusion model for protein structure inpainting that recovers masked sections using sequence and structural context, achieving comparable accuracy to existing models with limited data.

bioRxiv · Nov 21, 2023 · PreprintImmunology

Preclinical Characterization of the Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine

K. Modjarrad, Y. Che, W. Chen, H. Wu, C. I. Cadima, A. Muik, M. S. Maddur, K. R. Tompkins, L. T. Martinez, H. Cai, M. Hong, S. Mensah, B. Cumbia, L. Falcao, J. S. Chang, , K. Swanson

The monovalent Omicron XBB.1.5-adapted BNT162b2 mRNA vaccine elicits stronger neutralizing antibody responses against XBB.1.5 and related sublineages than the bivalent Wild Type + Omicron BA.4/5 vaccine.

bioRxiv · Nov 17, 2023Immunology

An mRNA-encoded, long-lasting Interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

J. D. Beck, M. Diken, M. Suchan, M. Streuber, E. Diken, L. Kolb, L. Allnoch, F. Vascotto, D. Peters, T. Beissert, O. Tuereci, S. Kreiter, M. Vormehr, U. Sahin

The paper shows that long-lasting mRNA-encoded IL2 restores immune responses in MHC class I-deficient cancers by activating neoantigen-specific CD8+ T cells.

bioRxiv · Jul 18, 2023Immunology

Progressive loss of conserved spike protein neutralizing antibody sites in Omicron sublineages is balanced by preserved T-cell recognition epitopes

A. Muik, B. G. Lui, H. Diao, Y. Fu, M. Bacher, A. Toker, J. Grosser, O. Ozhelvaci, K. Grikscheit, S. Hoehl, N. Kohmer, Y. Lustig, G. Regev-Yochay, S. Ciesek, K. Beguir, , U. Sahin

The paper examines how Omicron sublineages evade neutralizing antibodies but retain T-cell epitopes, suggesting T-cell immunity remains effective against these variants.

bioRxiv · Dec 15, 2022 · PreprintImmunology

Improved Neutralization of Omicron BA.4/5, BA.4.6, BA.2.75.2, BQ.1.1, and XBB.1 with Bivalent BA.4/5 Vaccine

J. Zou, C. Kurhade, S. Patel, N. Kitchin, K. Tompkins, M. Cutler, D. Cooper, Q. Yang, H. Cai, A. Muik, Y. Zhang, D.-Y. Lee, U. Sahin, A. S. Anderson, W. C. Gruber, , P.-Y. Shi

This study compares the neutralizing antibody responses induced by monovalent and bivalent BA.4/5 vaccines against multiple Omicron sublineages in individuals over 55 years old, finding the bivalent vaccine elicits stronger neutralization.

bioRxiv · Nov 17, 2022 · PreprintMicrobiology

Exposure to BA.4/BA.5 Spike glycoprotein drives pan-Omicron neutralization in vaccine-experienced humans and mice

A. Muik, B. G. Lui, M. Bacher, A.-K. Wallisch, A. Toker, C. I. C. Couto, A. Gueler, V. Mampilli, G. J. Schmitt, J. Mottl, T. Ziegenhals, S. Fesser, J. Reinholz, F. Wernig, K.-G. Schraut, , U. Sahin

This study shows that exposure to BA.4/BA.5 spike glycoprotein enhances neutralizing antibody breadth against Omicron variants in vaccinated humans and mice.

bioRxiv · Sep 21, 2022 · PreprintImmunology

Omicron BA.2 breakthrough infection enhances cross-neutralization of BA.2.12.1 and BA.4/BA.5

A. Muik, B. G. Lui, M. Bacher, A.-K. Wallisch, A. Toker, A. Finlayson, K. Krueger, O. Ozhelvaci, K. Grikscheit, S. Hoehl, S. Ciesek, O. Tuereci, U. Sahin

The paper shows that BA.2 breakthrough infection in vaccinated individuals enhances neutralization of BA.2.12.1 and BA.4/BA.5 compared to BA.1 breakthrough infection.

bioRxiv · Aug 2, 2022Immunology

Neutralization of Omicron sublineages and Deltacron SARS-CoV-2 by 3 doses of BNT162b2 vaccine or BA.1 infection

C. Kurhade, j. Zou, H. Xia, M. Liu, Q. Yang, M. Cutler, D. Cooper, A. Muik, U. Sahin, K. U. Jansen, P. Ren, X. Xie, K. A. Swanson, P.-Y. Shi

This study evaluates the neutralization of Omicron sublineages and Deltacron by BNT162b2 vaccine or BA.1 infection, finding BA.4/5 shows highest evasion.

bioRxiv · Jun 5, 2022Microbiology

Omicron breakthrough infection drives cross-variant neutralization and memory B cell formation

J. Quandt, A. Muik, N. Salisch, B. G. Lui, S. Lutz, K. Krueger, A.-K. Wallisch, P. Adams-Quack, M. Bacher, A. Finlayson, O. Ozhelvaci, I. Vogler, K. Grikscheit, S. Hoehl, U. Goetsch, , U. Sahin

bioRxiv · Apr 1, 2022 · PreprintImmunology

BNT162b2-Elicited Neutralization of Delta Plus, Lambda, and Other Variants

J. Liu, Y. Liu, H. Xia, J. Zou, S. Weaver, K. A. Swanson, H. Cai, M. Cutler, D. Cooper, A. Muik, K. U. Jansen, U. Sahin, X. Xie, P. R. Dormitzer, P.-Y. Shi

The paper assesses the neutralization ability of BNT162b2-elicited sera against SARS-CoV-2 variants, finding that all sera neutralize variants to titers of ≥80, indicating vaccine effectiveness against emerging strains.

bioRxiv · Sep 13, 2021 · PreprintMicrobiology

Neutralization of SARS-CoV-2 lineage B.1.1.7 pseudovirus by BNT162b2 vaccine-elicited human sera

A. Muik, A.-K. Wallisch, B. Saenger, K. A. Swanson, J. Muehl, W. Chen, H. Cai, R. Sarkar, O. Tuereci, P. R. Dormitzer, U. Sahin

The paper assesses the neutralizing activity of BNT162b2 vaccine-induced sera against SARS-CoV-2 B.1.1.7 pseudoviruses and finds equivalent neutralizing titers compared to the Wuhan strain.

bioRxiv · Jan 18, 2021Immunology