J. Yin

Single-molecule analysis reveals the phosphorylation of FLS2 governs its spatiotemporal dynamics and immunity

This study shows phosphorylation of FLS2 at Ser-938 affects its dynamics and immune response by directing it to AtRem1.3 nanodomains.

Click-free imaging of carbohydrate trafficking in live cells using an azido photothermal probe

This paper demonstrates click-free imaging of carbohydrate trafficking in live cells using azido photothermal probes, revealing trehalose recycling and protein interactions in mycobacteria and other organisms.

Unraveling the gut microbiota of Tibetan chickens: insights into highland adaptation and ecological advantages

This study compares the gut microbiota of Tibetan chickens from different environments to identify adaptations to high-altitude conditions.

YamOmics: A comprehensive data resource on yam multi-omics

YamOmics compiles and organizes multi-omics data from 41 yam species, providing genomic, transcriptomic, and plastomic data along with variant and expression information for yam research and breeding.

The phosphoproteome is a first responder in tiered cellular adaptation to chemical stress followed by proteomics and transcriptomics alteration

This study compares transcriptomics, proteomics, and phosphoproteomics responses in HepG2 and AC16 cells to chemical exposure, finding phosphoproteomics changes occur earlier and at lower concentrations than transcriptomics.

Study on the preparation of bovine milk exosomes and the stability of lyophilized powder

This study prepares bovine milk exosomes and evaluates the stability of their lyophilized powder, showing it can be stored at room temperature for 3 months and 2-8°C for 15 months.

Nanoscale Structural Mapping of Protein Aggregates in Live Cells Modeling Huntington's Disease

This paper uses MIP microscopy to map the nanoscale secondary structure of huntingtin protein aggregates in live yeast cells, revealing a β-sheet core and α-helix shell, and shows prion-dependent structural differences.

Requirement of microtubules for secretion of a micronemal protein CpTSP4 in the invasive stage of the apicomplexan Cryptosporidium parvum

This study identifies CpTSP4, a new micronemal protein in Cryptosporidium parvum, showing its secretion during invasion and dependence on microtubular trafficking and heparin-binding for host interaction.

Genome-wide Perturbation Analysis Screening System for Exosomes-Related Genes Based on the CRISPR/Cas9 Platform

The paper develops a CRISPR-UMI-based screening system to study exosome biogenesis, transport, and uptake mechanisms on a genome-wide scale.

Simultaneous targeting of AMPK and mTOR is a novel therapeutic strategy against prostate cancer

This study shows that targeting both AMPK and mTOR can inhibit prostate cancer metastasis by blocking the metabolic switch required for tumor growth in new environments.

A novel bacterial signal transduction system specifically senses and responds to peptidoglycan damage

This study identifies a bacterial two-component system that detects and responds to peptidoglycan damage, revealing its role in antibiotic resistance and tolerance.

Melanin enhances metastatic melanoma colonization by inhibiting ferroptosis

This study shows melanin protects melanoma cells from ferroptosis, enhancing metastasis, and suggests targeting melanin and ferroptosis could improve treatment of metastatic melanoma.

Stimulated Raman Photothermal Microscopy towards Ultrasensitive Chemical Imaging

This paper introduces a new spectroscopic imaging method that improves signal intensity by over 500-fold for chemical imaging.

Video-rate Mid-infrared Photothermal Imaging by Single Pulse Photothermal Detection per Pixel

This paper introduces a single pulse photothermal microscope for video-rate mid-infrared imaging, enabling observation of lipid dynamics and mapping fat storage in living systems.

A novel purity analysis method of bovine milk-derived exosomes by two-dimensional high-performance liquid chromatography

This paper introduces a 2D-HPLC method for analyzing the purity of bovine milk-derived exosomes, showing improved accuracy, precision, and efficiency compared to existing methods.

A Drug Repurposing Approach Reveals Targetable Epigenetic Pathways in Plasmodium vivax Hypnozoites

The paper identifies epigenetic inhibitors active against Plasmodium vivax hypnozoites through drug repurposing screens, showing epigenetic pathways are critical for hypnozoite quiescence.

Leafhopper transmits soybean stay-green associated virus to legume plants

This study identifies leafhoppers as vectors for SoSGV, a virus associated with soybean stay-green syndrome, and shows they can transmit the virus to legume plants.

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

This study shows that reduced GAS6 in synovial macrophages due to M1 polarization impairs efferocytosis, leading to inflammation and cartilage damage in obesity-associated osteoarthritis.

On-target inhibition of Cryptosporidium parvum by nitazoxanide (NTZ) and paclitaxel (PTX) validated using a novel MDR1-transgenic host cell model and algorithms to quantify on/off-target rates

The paper validates on-target and off-target effects of anti-Cryptosporidium drugs using a novel MDR1-transgenic host cell model and algorithms to quantify drug action contributions.

Heritability and host genomic determinants of switchgrass root-associated microbiota in field sites spanning its natural range.

This study examines how host genetics and environmental factors shape root microbiota in switchgrass across its native range, finding heritable variation and local microbial recruitment.

Elemental diet enriched in amino acids alters gut microbial community and prevents colonic mucus degradation in mice with colitis

This study shows that an amino acid-enriched elemental diet reduces mucolytic bacteria and protects the mucus layer in mice with colitis.

Cell-type specific transcriptomics reveals roles for root hairs and endodermal barriers in interaction with beneficial rhizobacterium

The paper uses cell-type-specific transcriptomics to show how WCS417 affects root cell types, revealing roles for root hairs in immunity and endodermal barriers in beneficial association.

Tumor-derived biomarkers beyond antigen expression enhance efficacy of CD276/B7H3 antibody-drug conjugate in metastatic prostate cancer

This study identifies biomarkers beyond B7H3 expression that predict response to a B7H3-ADC in metastatic prostate cancer models, improving therapeutic efficacy.

The origin and dynamics of cellular heterogeneity vary across lineage subtypes of castrate resistant prostate cancer

This study examines the origin and dynamics of cellular heterogeneity in different subtypes of castrate-resistant prostate cancer using patient-derived organoids and single-cell analyses, identifying distinct lineage plasticity patterns and therapeutic targets.

PSGL-1 directs early TCR signaling to repress metabolism and promote T cell exhaustion by modulating the TCF-1/TOX axis in CD8+ T cells.

This study shows PSGL-1 modulates TCF-1/TOX axis to repress metabolism and promote T cell exhaustion in CD8+ T cells, making it a therapeutic target for PD-1/PD-L1 resistant tumors.

Assessment of AI-based Protein Structure Prediction for the NLRP3 Target

This study evaluates AI-based protein structure prediction for NLRP3, showing that AI models can generate reliable structures useful for small-molecule drug discovery.

Patient-derived zebrafish xenograft models reveal ferroptosis as a fatal and druggable weakness in metastatic uveal melanoma

The paper develops a zebrafish xenograft model of metastatic uveal melanoma and identifies ferroptosis as a druggable vulnerability in tumors with BAP1 loss.

Molecular assembly of measles and Nipah virus: specific lipid binding drives conformational change and matrix polymerization

This study identifies how measles and Nipah virus M proteins bind specific lipids, inducing conformational changes that drive virion assembly.

Intelligent Resolution: Integrating Cryo-EM with AI-driven Multi-resolution Simulations to Observe the SARS-CoV-2 Replication-Transcription Machinery in Action

This study develops an AI-driven multi-resolution simulation workflow to study SARS-CoV-2 RTC dynamics, combining cryo-EM with mesoscale simulations and AI methods.

Epigenetic Remodeling by Vitamin C Potentiates the Differentiation of Mouse and Human Plasma Cells

This study shows vitamin C enhances plasma cell differentiation in mouse and human B cells by epigenetic remodeling via TET enzymes and STAT3-dependent mechanisms.