Generation of anti-tumor chimeric antigen receptors incorporating T cell signaling motifs
L. Balagopalan, T. Moreno, H. Qin, J. Yi, K. M. M. McIntire, N. Alvinez, S. Pallikkuth, M. E. Lee, H. Yamane, A. D. Tran, P. Youkharibache, R. E. Cachau, N. Taylor, L. E. Samelson
This paper develops novel Chimeric Adapter Proteins (CAPs) that enhance T cell signaling and anti-tumor efficacy compared to conventional CAR-T cells.
bioRxiv · Dec 25, 2022 · PreprintImmunology