H. Qin

Integrated Analysis of Single-Cell and Bulk RNA-Seq Data reveals that Ferroptosis-Related Genes Mediated the Tumor Microenvironment predicts Prognosis, and guides Drug Selection in Triple-Negative Breast Cancer

This study integrates single-cell and bulk RNA-seq data to identify ferroptosis-related genes in TNBC, developing a risk score model to predict prognosis and guide drug selection.

Advancing CAR T-Cell Therapy: Simultaneously Attack Tumor and Immunosuppressive Cells in the Tumor Microenvironment

This paper develops a PD-L1-targeting CAR T-cell therapy (MC9999) that effectively attacks both tumor and immunosuppressive cells in solid tumors.

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

This study identifies O-GlcNAcylation of mushroom body ribosomal subunits as essential for olfactory learning in Drosophila, showing that reducing O-GlcNAcylation impairs learning.

Mass spectrometry and split luciferase complementation assays reveal the MecA protein interactome of Streptococcus mutans

The paper identifies the MecA interactome of Streptococcus mutans using mass spectrometry and split luciferase complementation assays, revealing both Clp-dependent and proteolysis-independent regulatory mechanisms.

CAR T-cell therapy- Paving the way for sensitized kidney transplant patients.

This paper explores using CAR T-cells targeting BAFF-R to treat sensitized kidney transplant patients, showing cytotoxicity against autologous B cells and paving the way for clinical trials.

BacScan: An Unbiased and Genome-Wide Approach to Identify Bacterial Highly Immunogenic Proteins

BacScan identifies highly conserved immunogenic bacterial proteins across serotypes, showing potential for vaccine development.

Structure, Dynamics and Free Energy Studies on the Effect of Spot Mutations on SARS-CoV-2 Spike Protein Binding with ACE2 Receptor

This study uses MD simulations and free energy perturbation to analyze how spot mutations in SARS-CoV-2 RBD affect binding to ACE2, identifying which mutations strengthen or weaken the interaction.

Dimeric Transmembrane Structure of the SARS-CoV-2 E Protein

The paper determines the dimeric structure of the SARS-CoV-2 E protein using NMR and simulations, identifying a hydrophobic pore and potential drug-binding site.

Generation of anti-tumor chimeric antigen receptors incorporating T cell signaling motifs

This paper develops novel Chimeric Adapter Proteins (CAPs) that enhance T cell signaling and anti-tumor efficacy compared to conventional CAR-T cells.

Consortium bibliometric analysis of hotspots and frontiers of immunotherapy in pancreatic cancer

This paper conducts a bibliometric analysis of immunotherapy research in pancreatic cancer, identifying key trends, hotspots, and future directions.

Real-time feeding behavior monitoring by electrical penetration graph rapidly reveals host plant susceptibility to crapemyrtle bark scale (Hemiptera: Eriococcidae)

This paper develops an EPG-based method to rapidly assess plant susceptibility to crapemyrtle bark scale by analyzing real-time feeding behavior parameters.

Green Lacewing Chrysoperla rufilabris (Neuroptera: Chrysopidae) is a potential biological agent for controlling crapemyrtle bark scale (Hemiptera: Eriococcidae)

This study confirms that larval green lacewing Chrysoperla rufilabris preys on crapemyrtle bark scale at different life stages and shows its potential as a biological control agent.

Development of the First Tractable Genetic System for Parvimonas micra, a Ubiquitous Pathobiont in Human Dysbiotic Disease

This paper develops the first genetic system for Parvimonas micra, enabling molecular studies of its role in disease.

Virtually the same? Evaluating the effectiveness of remote undergraduate research experiences

This study evaluates remote undergraduate research experiences during the pandemic, finding similar scientific integration outcomes to in-person programs but with differences based on prior experience.

Rescuable effect of R-salbutamol in LPS-induced immune dysfunction of sepsis

This study investigates the preventive and therapeutic effects of R-salbutamol, S-salbutamol, and their racemic mixture in a mouse model of LPS-induced sepsis, finding R-salbutamol improves survival and lung function while S-salbutamol worsens outcomes.

"How do we do this at a distance?!" A descriptive study of remote undergraduate research programs during COVID-19

This study describes and evaluates remote undergraduate research programs in life sciences during the COVID-19 pandemic, identifying strengths, weaknesses, and recommendations for improvement.

State-Transition Analysis of Time-Sequential microRNA Expression Predicts Development of Acute Myeloid Leukemia

This study uses time-sequential miRNA expression data from a mouse AML model to identify state transitions during leukemogenesis and shows the model predicts time to AML development.

Time-restricted feeding near dawn entrains long-term behavioral changes through the suprachiasmatic nucleus

This study shows that time-restricted feeding near dawn alters long-term mouse behavior through SCN GABAergic neurons by affecting exosome-related genes and Kcc2.

Counteracting Genome Instability by p53-dependent Mintosis

The paper identifies a p53-dependent process called mintosis that eliminates aneuploid mitotic progenies through entosis to counteract genome instability.

NDRG2 Regulates Adherens Junction Integrity to Restrict Colitis and Tumorigenesis

This study shows NDRG2 maintains intestinal epithelial barriers by regulating E-cadherin and adherens junctions, preventing colitis and tumor development.

Speed and diffusion of kinesin-2 are competing limiting factors in flagellar length control model

The paper models how kinesin-2 motor speed and diffusion coefficient influence flagellar length in Chlamydomonas, showing two distinct regulatory regimes based on length and mutation effects.