Author

M. E. Mangoni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electrophysiology· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

P. Mesirca· 3 shared A. Bucchi· 1 shared A. Fernandez· 1 shared A. G. Torrente· 1 shared A. Hivonnait· 1 shared A. Moroni· 1 shared A. Persello· 1 shared A. Porro· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersPhysiology

P. Mesirca

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Optical control of cardiac rhythm by in vivo photoactivation of an ERG channel peptide inhibitor

J. Montnach, H. Millet, A. Persello, H. Meudal, S. De Waard, P. Mesirca, B. Ribeiro, J. Richard, A. Hivonnait, A. Tessier, B. Lauzier, F. Charpentier, M. E. Mangoni, C. Landon, C. jopling, M. De Waard

This study uses photopharmacology to control cardiac rhythm in vivo by uncaging a peptide inhibitor of the ERG channel, showing spatially restricted effects on heart rate and conduction.

bioRxiv · Mar 23, 2023 · PreprintPharmacology & Toxicology

Mouse lemur, a new animal model to investigate cardiac pacemaker activity in primates.

M. L. DiFrancesco, R. Davaze, E. Torre, P. Mesirca, M. Marrot, C. Lautier, P. Fontes, J. Cuoq, A. Fernandez, N. Lamb, F. Pifferi, N. Mestre Frances, M. E. Mangoni, A. G. Torrente

This study characterizes cardiac pacemaker activity in mouse lemurs, revealing similarities to human SAN function and potential for modeling age-related cardiovascular dysfunctions.

bioRxiv · Oct 25, 2021 · PreprintPhysiology

Structure-guided design of a cell penetrating peptide preventing cAMP modulation of HCN channels

A. Moroni, A. Saponaro, F. Cantini, A. Porro, A. Bucchi, D. DiFrancesco, V. Maione, C. Donadoni, B. Introini, P. Mesirca, M. E. Mangoni, G. Thiel, L. Banci, B. Santoro

The paper designs a cell-penetrating peptide, TRIPnano, that blocks cAMP modulation of HCN channels by competing for binding and inducing allosteric changes, reducing spontaneous action potential firing in sinoatrial node myocytes by 30%.

bioRxiv · Jan 24, 2018Physiology