A general computational design strategy for stabilizing viral class I fusion proteins
K. J. Gonzalez, J. Huang, M. F. Criado, A. Banerjee, S. M. Tompkins, J. J. Mousa, E. M. Strauch
This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.
bioRxiv · Mar 16, 2023Microbiology