Author

K. J. Gonzalez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Assay:protein structure· 2 Approach:statistical model· 2 Approach:experimental assay· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:structural biology· 1

Frequent Co-Authors

E.-M. Strauch· 2 shared A. Banerjee· 1 shared A. Eletsky· 1 shared C. M. West· 1 shared E. M. Strauch· 1 shared H. van der Wel· 1 shared H. W. Kim· 1 shared J. C. Blanco· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBioengineering

E.-M. Strauch

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Author profile →

3 papers

Recent·Most cited

Systematic computer-aided disulfide design as a general strategy to stabilize prefusion class I fusion proteins

K. J. Gonzalez, K. Yim, J. C. Blanco, M. S. Boukhvalova, E.-M. Strauch

This paper develops a computational method to identify stabilizing disulfide bonds for prefusion class I fusion proteins, demonstrating its effectiveness in stabilizing the RSV F protein and providing protection in a cotton rat model.

bioRxiv · Feb 29, 2024Bioengineering

A general computational design strategy for stabilizing viral class I fusion proteins

K. J. Gonzalez, J. Huang, M. F. Criado, A. Banerjee, S. M. Tompkins, J. J. Mousa, E. M. Strauch

This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.

bioRxiv · Mar 16, 2023Microbiology

Skp1 Dimerization Conceals its F-box Protein Binding Site

H. W. Kim, A. Eletsky, K. J. Gonzalez, H. van der Wel, E.-M. Strauch, J. H. Prestegard, C. M. West

This paper investigates how Skp1 dimerization hides its F-box protein binding site, showing that a mutation disrupts dimerization and allows Skp1 to bind F-box proteins.

bioRxiv · Jan 26, 2020Biochemistry