S. M. Tompkins

Differential Cross-Protective Immunity is Elicited by Infection with Contemporary Influenza B Lineage Viruses

This study shows that contemporary Influenza B Victoria viruses provide cross-protection against Yamagata viruses, while Yamagata viruses do not offer similar protection, suggesting neuraminidase antibodies may be key to this asymmetry.

Pandemic Risk Assessment for a Swine Influenza A Virus in Comparative Human Substrates

The paper assesses a swine influenza A virus in animal and human cell models to evaluate pandemic risk, finding varied replication potential across models.

Swine influenza A virus isolates containing the pandemic H1N1 origin matrix gene elicit greater disease in the murine model

This study shows that swine influenza A viruses with the pandemic H1N1 origin matrix gene cause more severe disease in mice compared to those with the classical swine matrix gene.

A general computational design strategy for stabilizing viral class I fusion proteins

This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.

Feline Coronavirus Infection of Domestic Cats Causes Development of Cross-Reactive Antibodies to SARS-CoV-2 Receptor Binding Domain

This study shows that feline coronavirus-infected cats develop cross-reactive antibodies to SARS-CoV-2 RBD, despite low sequence similarity, suggesting potential for a pan-CoV vaccine.

4-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses

This study shows 4-Fluorouridine effectively treats seasonal and highly pathogenic influenza viruses in cell culture, organoids, and animal models, preventing lethal infection and transmission.

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

A Low-Dose Triple Antibody Cocktail Against the Ectodomain of the Matrix Protein 2 of Influenza A Is A Universally Effective and Viral Escape Mutant Resistant Therapeutic Agent

This paper develops a low-dose triple antibody cocktail targeting the conserved M2e antigen of influenza A, showing universal efficacy and resistance to viral escape mutants in mouse models.

Sialic acid-Dependent Binding and Viral Entry of SARS-CoV-2

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

Heparan sulfate proteoglycans as attachment factor for SARS-CoV-2

This study identifies heparan sulfate proteoglycans as an attachment factor for SARS-CoV-2 and suggests HS oligosaccharides could inhibit viral binding.

Randomly primed, strand-switching MinION-based sequencing for the detection and characterization of cultured RNA viruses

This study evaluates a MinION-based sequencing method for detecting and characterizing RNA viruses using random priming and strand-switching, showing its effectiveness for known and unknown viruses.