Author

J. J. Mousa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Assay:structural biology· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

J. Huang· 7 shared J. Murray· 3 shared A. Banerjee· 2 shared A. D. Gingerich· 2 shared A. Pena-Briseno· 2 shared F. Royer· 2 shared S. M. Tompkins· 2 shared A. Beavis· 1 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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7 shared papersImmunology

J. Huang

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

A general computational design strategy for stabilizing viral class I fusion proteins

K. J. Gonzalez, J. Huang, M. F. Criado, A. Banerjee, S. M. Tompkins, J. J. Mousa, E. M. Strauch

This paper presents a computational strategy to stabilize viral class I fusion proteins by designing mutations that favor the prefusion state over the postfusion state, validated through structural and immunological testing.

bioRxiv · Mar 16, 2023Microbiology

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

A. Beavis, Z. Li, K. Briggs, M. Diaz, E. Wrobel, M. Najera, D. An, N. Orr-Burks, J. Murray, P. Pati, J. Huang, J. J. Mousa, L. Hao, T.-Y. Hsiang, M. J. Gale, , B. He

This paper evaluates the immunogenicity and efficacy of PIV5-vectored COVID-19 vaccines against SARS-CoV-2 variants in hamsters, showing they induce strong neutralizing antibodies and provide protection as single doses or boosters.

bioRxiv · Jun 7, 2022 · PreprintMicrobiology

Structural basis for ultrapotent neutralization of human metapneumovirus

A. Banerjee, J. Huang, S. Rush, J. Murray, A. D. Gingerich, F. Royer, C.-L. Hsieh, R. A. Tripp, J. S. McLellan, J. J. Mousa

This study identifies a potent monoclonal antibody against hMPV and determines its structure, revealing a novel epitope for therapeutic development.

bioRxiv · Mar 14, 2022 · PreprintImmunology

A Pan-Pneumovirus vaccine based on immunodominant epitopes of the fusion protein

J. Huang, R. Miller, J. J. Mousa

This study designs and tests a chimeric fusion protein vaccine (RHMS-1) combining immunodominant epitopes from RSV and hMPV F proteins, showing protection against both viruses in mice.

bioRxiv · Feb 24, 2022Immunology

Differential recognition of computationally optimized H3 hemagglutinin influenza vaccine candidates by human antibodies

N. Abbadi, K. Nagashima, A. Pena-Briseno, T. Ross, J. J. Mousa

This study evaluates the antigenic and structural features of computationally optimized H3 HA influenza vaccine candidates, showing that TJ5 and J4 are better recognized by human B cells and mAbs than NG2 and a wild-type HA.

bioRxiv · Feb 24, 2022Immunology

Structure, immunogenicity, and conformation-dependent receptor binding of the post-fusion human metapneumovirus F protein

J. Huang, P. Chopra, L. Liu, T. Nagy, J. Murray, R. Tripp, G.-J. Boons, J. J. Mousa

This study determines the structure of post-fusion hMPV B2 F protein, assesses its receptor binding and immunogenicity, and shows it induces neutralizing antibodies against multiple hMPV strains.

bioRxiv · May 19, 2021Microbiology

Broadly reactive human monoclonal antibodies targeting the pneumococcal histidine triad protein protect against fatal pneumococcal infection

J. Huang, A. D. Gingerich, F. Royer, A. V. Paschall, A. Pena-Briseno, F. Y. Avci, J. J. Mousa

The paper isolates human monoclonal antibodies against pneumococcal proteins PhtD and PspA, showing protection against pneumococcal infection in mice.

bioRxiv · Feb 17, 2021Immunology

Antibody recognition of the Pneumovirus fusion protein trimer interface

J. Huang, D. Diaz, J. J. Mousa

This study identifies a novel epitope on the hMPV F protein recognized by neutralizing antibodies, revealing structural dynamics and glycan interactions important for vaccine design.

bioRxiv · May 20, 2020Immunology