Author

L. M. Butler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 11 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 12 Approach:experimental assay· 11 Research Focus:cancer & tumor microenvironment· 6 Research Focus:cell type annotation· 6 Assay:bulk RNA-seq· 4 Assay:metabolomics· 4 Research Focus:cell signaling & trafficking· 3 Assay:proteomics· 3

Frequent Co-Authors

C. Y. Mah· 5 shared J. Dehairs· 5 shared J. V. Swinnen· 5 shared A. J. Hoy· 4 shared D. J. Lynn· 4 shared L. A. Selth· 4 shared Z. D. Nassar· 4 shared L.-E. Quek· 3 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersCancer Biology

C. Y. Mah

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Author profile →

12 papers

Recent·Most cited

CPT1a regulates the delivery of extracellular fatty acids for cardiolipin turnover in prostate cancer cells.

N. T. Santiappillai, M. F. Hakeem-Sanni, A. Withy, L. M. Butler, L.-E. Quek, A. J. Hoy

The paper shows that CPT1a regulates the uptake of extracellular fatty acids into mitochondria for cardiolipin remodeling in prostate cancer cells, despite these fatty acids being minor contributors to the TCA cycle.

bioRxiv · Jan 16, 2024 · PreprintCancer Biology

Integration of Multiple Spatial-Omics Modalities Reveals Unique Insights into Molecular Heterogeneity of Prostate Cancer

W. Zhang, X. Spotbeen, S. Vanuytven, S. Kint, T. Sarretto, F. Socciarelli, K. Vandereyken, J. Dehairs, J. Idkowiak, D. Wouters, J. I. Alvira Larizgoitia, G. Partel, A. Ly, V. de Laat, M. J. Q. Mantas, , J. V. Swinnen

This paper integrates multiple spatial-omics modalities in prostate cancer samples to reveal molecular heterogeneity and correlations between lipids and gene expression.

bioRxiv · Aug 28, 2023 · PreprintCancer Biology

Ultrastructural analysis of prostate cancer tissue provides insights into androgen-dependent adaptations to membrane contact site establishment

L. M. Butler, E. Evergren

This study examines membrane contact sites in prostate cancer tissue, finding increased ER-mitochondria contacts in intermediate Gleason score samples, which are reduced by enzalutamide treatment.

bioRxiv · May 10, 2023Cancer Biology

Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer

C. Y. Mah, A. D. T. Nguyen, T. Niijima, M. Helm, J. Dehairs, F. J. Ryan, N. Ryan, I. G. Mills, J. V. Swinnen, D. J. Lynn, Z. D. Nassar, L. M. Butler

This study identifies DECR2 as a key driver of treatment resistance in advanced prostate cancer by regulating lipid metabolism and cell cycle progression.

bioRxiv · Nov 5, 2022Cancer Biology

ACSM1 and ACSM3 regulate prostate cancer fatty acid metabolism to promote tumour growth and constrain ferroptosis

R. Shrestha, Z. D. Nassar, A. R. Hanson, R. Iggo, S. L. Townley, J. Dehairs, C. Y. Mah, M. Helm, M. Alizadeh-Ghodsi, M. Pickering, M. J. Watt, L.-E. Quek, A. J. Hoy, W. D. Tilley, J. V. Swinnen, , L. A. Selth

This study identifies ACSM1 and ACSM3 as AR-regulated factors that promote prostate cancer growth by enhancing fatty acid metabolism and suppressing ferroptosis.

bioRxiv · Oct 13, 2022 · PreprintCancer Biology

snPATHO-seq: unlocking the FFPE archives for single nucleus RNA profiling

A. F. Vallejo, K. Harvey, T. Wang, K. Wise, L. M. Butler, J. Polo, J. T. Plummer, A. Swarbrick, L. G. Martelotto

This paper introduces snPATHO-Seq, a method for high-quality single nucleus RNA sequencing from FFPE samples, showing improved sensitivity and accuracy compared to existing methods.

bioRxiv · Aug 23, 2022 · PreprintCancer Biology

Lipidomic profiling of clinical prostate cancer reveals targetable alterations in lipid composition

L. M. Butler, C. Y. Mah, J. Machiels, A. D. Vincent, S. Irani, S. Mutuku, X. Spotbeen, M. Bagadi, D. Waltregny, M. Moldovan, J. Dehairs, F. Vanderhoydonc, K. Bloch, R. Das, J. Stahl, , J. V. Swinnen

The paper profiles lipidomes in prostate cancer tissues and identifies targetable lipid alterations linked to AR signaling and therapeutic response.

bioRxiv · Oct 27, 2020Cancer Biology

A feedback loop between the androgen receptor and 6-phosphogluoconate dehydrogenase (6PGD) drives prostate cancer growth

J. L. Gillis, J. A. Hinneh, N. K. Ryan, S. Irani, M. Moldovan, R. K. Shrestha, L.-E. Quek, A. J. Hoy, J. Holst, M. M. Centenera, I. G. Mills, D. J. Lynn, L. A. Selth, L. M. Butler

This study identifies a feedback loop between the androgen receptor and 6PGD that drives prostate cancer growth and shows that targeting both improves therapeutic efficacy.

bioRxiv · Sep 2, 2020Cancer Biology

eEF2 kinase enhances the expression of PD-L1 by promoting the translation of its mRNA

C. G. Proud, Y. Wu, J. Xie, X. Jin, R. V. Lenchine, X. Wang, D. M. W. Fang, Z. NASSAR, L. M. Butler, J. Li

This study shows that eEF2K enhances PD-L1 expression by promoting its mRNA translation through a uORF in the 5-UTR, making cancer cells more vulnerable to immune attack.

bioRxiv · Sep 1, 2020Biochemistry

Bringing the pancreas patient back to the bench: Ex vivo culture of intact human patient derived pancreatic tumour tissue

J. Kokkinos, G. Sharbeen, K. S. Haghighi, R. M. C. Ignacio, C. Kopecky, E. Gonzales-Aloy, J. Youkhana, E. Pandzic, C. Boyer, T. P. Davis, L. M. Butler, D. Goldstein, J. A. McCarroll, P. A. Phillips

This paper develops an ex vivo explant model of human pancreatic tumour tissue that maintains 3D architecture and microenvironmental cues, enabling study of PDAC biology and therapeutic response.

bioRxiv · Jul 30, 2020Cancer Biology

DECR1 is an androgen-repressed survival factor that regulates PUFA oxidation to protect prostate tumor cells from ferroptosis

Z. D. Nassar, C. Y. Mah, J. Dehairs, I. J. G. Burvenich, S. Irani, M. M. Centenera, R. K. Shrestha, M. Moldovan, A. S. Don, A. M. Scott, L. G. Horvath, D. J. Lynn, L. A. Selth, A. J. Hoy, J. V. Swinnen, L. M. Butler

This study identifies DECR1 as an androgen-repressed gene that promotes prostate cancer cell survival by facilitating PUFA oxidation and preventing ferroptosis.

bioRxiv · Dec 6, 2019Cancer Biology

MicroRNA-194 promotes lineage plasticity in advanced prostate cancer

R. C. Fernandes, J. Toubia, S. Townley, A. R. Hanson, B. K. Dredge, K. A. Pillman, A. G. Bert, R. Iggo, R. Das, MURAL investigators, D. Obinata, S. Sandhu, G. P. Risbridger, R. A. Taylor, M. G. Lawrence, , L. Selth

This study identifies miR-194 as a regulator of lineage plasticity in prostate cancer by targeting FOXA1 and promoting transdifferentiation to a neuroendocrine-like state.

bioRxiv · Sep 12, 2019 · PreprintCancer Biology