Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling
A. N. Stratman, O. M. Farrelly, C. M. Mikelis, M. F. Miller, Z. Wang, V. N. Pham, A. E. Davis, M. C. Burns, S. A. Pezoa, D. Castranova, T. M. Kilts, G. E. Davis, J. S. Gutkind, B. M. Weinstein
The paper shows that inhibiting phosphoinositide recycling in endothelial cells reduces tumor growth and angiogenesis by impairing VEGF signaling.
bioRxiv · Apr 18, 2019Cell Biology