Smooth muscle-derived adventitial progenitor cells promote key cell type transitions controlling plaque stability in atherosclerosis in a Klf4-dependent manner
M. C. Weiser-Evans, A. M. Dubner, S. Lu, A. J. Jolly, K. A. Strand, M. F. Mutryn, T. Hinthorn, T. Noble, R. A. Nemenoff, K. S. Moulton, M. W. Majesky
This study shows that Klf4-dependent transitions in adventitial progenitor cells affect plaque stability in atherosclerosis by altering fibroblast, SMC, and macrophage phenotypes.
bioRxiv · Jul 18, 2023 · PreprintPathology