R. A. Nemenoff

This study shows that Klf4-dependent transitions in adventitial progenitor cells affect plaque stability in atherosclerosis by altering fibroblast, SMC, and macrophage phenotypes.

This paper describes a method to validate sgRNAs that generate RET and NTRK1 fusion oncogenes in murine models, demonstrating their efficacy in creating tumor models responsive to targeted therapies.

This paper develops three novel murine KRASG12C-driven lung cancer cell lines to evaluate responses to KRASG12C inhibitors and identify combination strategies for improved therapeutic outcomes.

This study investigates immune checkpoint activity in ADPKD, finding that dual checkpoint inhibition improves disease outcomes in adult-onset models.

This paper shows that adaptive immunity enhances the durability of alectinib response in EML4-ALK lung cancer models, with CD8+ T cells playing a key role.

This study shows that cancer cell expression of MHCII affects T cell infiltration and response to anti-PD-1 therapy in lung adenocarcinoma.

This study identifies tumor-intrinsic IFN-gamma signaling as a determinant of anti-PD-1 response in NSCLC by altering the tumor microenvironment.