DNA damage dependent hypomethylation regulates the pro-angiogenic LncRNA MEG9
C. Espinosa-Diez, R. Wilson, R. Mukherjee, M. Feltham, C. Hudson, R. Ruhl, S. Anand
The paper shows DNA damage reduces DNMTs in endothelial cells, leading to increased MEG9 expression, which protects cells from DNA damage-induced death and promotes angiogenesis.
bioRxiv · Oct 14, 2018 · PreprintCell Biology