R. Ruhl

Tumor cell intrinsic RIG-I activation co-opts the host microenvironment to drive immune mediated tumor rejection

This study shows that activating RIG-I in tumor cells enhances anti-tumor immunity and improves response to checkpoint therapy, suggesting a strategy for cancer vaccines.

DNA damage-induced lncRNA MEG9 impacts angiogenesis

This study identifies MEG9 as a cytoprotective lncRNA in endothelial cells that modulates angiogenesis and vascular homeostasis in response to DNA damage.

DNA damage dependent hypomethylation regulates the pro-angiogenic LncRNA MEG9

The paper shows DNA damage reduces DNMTs in endothelial cells, leading to increased MEG9 expression, which protects cells from DNA damage-induced death and promotes angiogenesis.

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence and angiogenic signaling

The paper shows that miR-494 and miR-99b regulate the MRN complex, affecting DNA repair, senescence, and angiogenesis through VEGF and CD44 pathways.

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

This study shows that miR-15a regulates SMPD1 in endothelial cells, affecting angiogenesis and tumor growth in response to radiation.

MicroRNA-451a regulates colorectal cancer radiosensitivity

This study identifies miR-451a as a regulator of colorectal cancer radiosensitivity, showing it inhibits proliferation and enhances radiation response.