S. Anand

CDK12/CDK13 inhibition disrupts a transcriptional program critical for glioblastoma survival

This study shows that inhibiting CDK12 and CDK13 reduces glioma cell proliferation and migration, and disrupts transcription and cell cycle progression in glioblastoma.

Cholesterol-associated Locus EHBP1 Protects against NASH Fibrosis

This study identifies EHBP1 as a protective locus against NASH fibrosis by regulating cholesterol metabolism and interacting with other cholesterol-related genes.

Machine Learning-Guided Antibody Engineering That Leverages Domain Knowledge To Overcome The Small Data Problem

This paper presents a machine learning platform that enhances antibody affinity and neutralizing potency using domain knowledge and limited experimental data.

Tumor cell intrinsic RIG-I activation co-opts the host microenvironment to drive immune mediated tumor rejection

This study shows that activating RIG-I in tumor cells enhances anti-tumor immunity and improves response to checkpoint therapy, suggesting a strategy for cancer vaccines.

DNA damage-induced lncRNA MEG9 impacts angiogenesis

This study identifies MEG9 as a cytoprotective lncRNA in endothelial cells that modulates angiogenesis and vascular homeostasis in response to DNA damage.

HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia

This study identifies a repressive HOXA9-SAFB complex in AML that maintains disease by inhibiting differentiation and apoptosis, suggesting therapeutic targets.

Small Molecule Protein Assembly Modulators with Pan-Cancer Therapeutic Efficacy

The paper identifies two small molecules with pan-cancer cytotoxicity and validates their anti-tumor effects in xenograft models, showing they target TRIM28/KAP1-containing complexes involved in cancer survival.

Distinct selection signatures during domestication and improvement in crops: a tale of two genes in mungbean

This study compares selection signatures in mungbean domestication and improvement, identifying distinct genomic footprints associated with different genes and selective pressures.

Monkey Pox Virus (MPXV): Phylogenomics, Host-Pathogen Interactome, and Mutational Cascade

This study analyzes Monkeypox virus genome sequences to investigate its phylogenomics, host-pathogen interactions, and mutational patterns, identifying key proteins and mutations associated with evolutionary dynamics and host evasion.

High-resolution lung adenocarcinoma expression subtypes identify tumors with dependencies on MET, CDK4, CDK6, and PD-L1

The paper identifies five lung adenocarcinoma expression subtypes using consensus hierarchical clustering and finds subtype-specific dependencies on MET, CDK4, CDK6, and PD-L1, which could guide targeted therapies.

Genetic Subtypes of Smoldering Multiple Myeloma are associated with Distinct Pathogenic Phenotypes and Clinical Outcomes

This study identifies six genetic subtypes of smoldering multiple myeloma associated with distinct clinical outcomes and progression risks.

A cell-based screen identifies HDAC inhibitors as activators of RIG-I signaling

The paper identifies HDAC inhibitors as activators of RIG-I signaling through a cell-based screen and shows their potential in enhancing immune responses in cancer.

Th1/17 Cells Infiltrate Murine Cytomegalovirus-Infected Renal Allografts via Virus-Induced CCL20 and Promote Th1 Cells through IL-17A.

This study shows CMV infection increases Th17 cells in renal grafts via CCL20, which correlates with Th1 cells and reduces Tregs, and IL-17A inhibition lowers Th17 cells without affecting antiviral Th1 cells.

Single-nucleus cross-tissue molecular reference maps to decipher disease gene function

The paper develops a cross-tissue single-nucleus RNA-seq atlas to identify cell types and gene functions in health and disease.

Mimicking the Human Tympanic Membrane: the Significance of Geometry

This paper investigates how the geometry of tissue-engineered tympanic membranes affects their mechanical and acoustic properties using computational models and experimental tests.

Correlation Coefficient Based Automatic Optic Disc Detection From Retinal Images

The paper describes an algorithm for automatic optic disc detection in retinal images using circular brightness and correlation coefficient, achieving 95% accuracy on DRIVE database images.

A miR-494 dependent feedback loop regulates ER stress

This study identifies miR-494 as a regulator of ER stress through a feedback loop, showing it dampens ER stress and its inhibition exacerbates it in vitro and in vivo.

Comparative Genomic Analysis of Rapidly Evolving SARS-CoV-2 Viruses Reveal Mosaic Pattern of Phylogeographical Distribution

This study analyzes SARS-CoV-2 genomes from global isolates to reveal mosaic phylogeographical patterns and identify unique mutations associated with immune evasion mechanisms.

DNA damage dependent hypomethylation regulates the pro-angiogenic LncRNA MEG9

The paper shows DNA damage reduces DNMTs in endothelial cells, leading to increased MEG9 expression, which protects cells from DNA damage-induced death and promotes angiogenesis.

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence and angiogenic signaling

The paper shows that miR-494 and miR-99b regulate the MRN complex, affecting DNA repair, senescence, and angiogenesis through VEGF and CD44 pathways.

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via modulation of acid sphingomyelinase

This study shows that miR-15a regulates SMPD1 in endothelial cells, affecting angiogenesis and tumor growth in response to radiation.

MicroRNA-451a regulates colorectal cancer radiosensitivity

This study identifies miR-451a as a regulator of colorectal cancer radiosensitivity, showing it inhibits proliferation and enhances radiation response.